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1. #3rd degree burn healing manual#
2. #3rd degree burn healing skin#

Furthermore, stem cells are abundant in origin and can be isolated from adipose tissue, umbilical cord, embryo, bone, gingiva, and other tissues. Stem cell therapy is an emerging method based on proliferation and/or differentiation of transplanted stem cells to repair or even replace damaged tissues or organs, which in effect offers new possibilities for regenerative medicine. Therefore, more effective burn treatment drugs are urgently needed to treat burn wounds. Although there are various treatment options, there is no consensus yet on the best treatment for severe burns such as deep partial-thickness and full-thickness burns. Various healing drugs including DNA, stem cells, growth factors, and siRNA have been pursued to promote burn wound repair and regeneration. Subsequently, the formation of scar and contracture will lead to considerable decrease of joint activity, and even the loss of function.

#3rd degree burn healing skin#

However, for severe burns, skin grafts can cause harmful psychological effects and severe disfigurement of the donor’s skin. Although the skin has the ability to heal itself, severe burns require a variety of interventions, such as healing drugs, debridement, and skin grafts. The primary goal of burn treatment is effective wound management, which largely determines the survival and prognosis of patients with severe burns. After effective and timely treatment, many patients can retain a considerable quality of life. The World Health Organization indicated that nearly 300,000 deaths occur annually, worldwide, from burns, but most of them not caused by fatal burns. In general, stem cells can potentially become a novel therapy candidate for burn wounds.Įven at current medical levels, burn remains a serious public health problem with high morbidity and mortality worldwide. These findings also demonstrate the need for considering variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness. Meta-analysis showed that stem cell therapy exerts a healing function for burn wounds, mainly through angiogenesis and anti-inflammatory actions. Furthermore, stem cell therapy seemed to exert more beneficial effects on burn wounds with second-degree (SMD 7.53, 95% CI 3.11 to 11.95) compared with third-degree (SMD 2.65, 95% CI 1.31 to 4.00).

Subgroup analyses indicated that hair follicle stem cells seemed to exert more beneficial effects on animals with burn wounds (SMD 7.53, 95% CI 3.11 to 11.95) compared with other stem cells. The overall meta-analysis showed that stem cell therapy significantly improved burn healing rate (SMD 3.06, 95% CI 1.98 to 4.14), irrespective of transplant type, burn area, and treatment method in the control group. RevMan 5.3 was used for all data analysis. No language or time restrictions were enforced.

#3rd degree burn healing manual#

In addition, a manual search of references of studies was performed to obtain potential studies. Twenty-two studies with 595 animals were identified by searching PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to.

The systematic review was performed for these preclinical studies to assess the efficacy and possible mechanisms of stem cells in treating burn wounds. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. Although there are various treatment options available, there is no consensus on the best treatment for severe burns as of yet. Burns remain a serious public health problem with high morbidity and mortality rates worldwide.